Article
The role of apolipoprotein N-acyl transferase, Lnt, in the lipidation of factor H binding protein of Neisseria meningitidis strain MC58 and its potential as a drug target.
British journal of pharmacology - 1 Jul 2017
da Silva R A G, Churchward C P, Karlyshev A V, Eleftheriadou O, Snabaitis A K, Longman M R, Ryan A, Griffin R
Abstract excerpt
BACKGROUND AND PURPOSE: The level of cell surface expression of the meningococcal vaccine antigen, Factor H binding protein (FHbp) varies between and within strains and this limits the breadth of strains that can be targeted by FHbp-based vaccines. The molecular pathway controlling expression of FHbp at the cell surface, including its lipidation, sorting to the outer membrane and export, and the potential...
Topics
- Acyltransferases
- Anti-Bacterial Agents
- Antigens, Bacterial
- Bacterial Proteins
- Ciprofloxacin
- Dose-Response Relationship, Drug
- Enzyme Inhibitors
- Microbial Sensitivity Tests
- Mutation
- Neisseria meningitidis
- Rifampin
- Structure-Activity Relationship