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Mitochondrial DNA content and oxidation in bipolar disorder and its role across brain regions

4 Dec 2019

Abstract excerpt

The underlying pathology of bipolar disorder remains unknown, though evidence is accumulating to support a role of mitochondrial dysfunction. In this study, we aim to investigate electron transport chain complex I subunit NDUFS7 protein expression; mtDNA content; common deletion; and oxidation in the Broadmann area 24 (BA24), cerebellum, hippocampus, and prefrontal cortex from patients with bipolar disorder,...

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PMID: 31797868
DOI: 10.1038/s41537-019-0089-5

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