Article
EGFR mutation status of paired cerebrospinal fluid and plasma samples in EGFR mutant non-small cell lung cancer with leptomeningeal metastases.
Cancer chemotherapy and pharmacology - 1 Dec 2016
Zhao Jing, Ye Xin, Xu Yan, Chen Minjiang, Zhong Wei, Sun Yun, Yang Zhenfan, Zhu Guanshan, Gu Yi, Wang Mengzhao
Abstract excerpt
PURPOSE: Central nervous system (CNS) is the prevalent site for metastases in epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)-relapsed NSCLC patients. To understand the EGFR mutation status in paired cerebrospinal fluid (CSF) and plasma samples after EGFR-TKI treatment failure might be useful to guide the treatment of intra- and extracranial tumors in those patients. METHODS: Paired CSF...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.