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Article

Cerebrospinal fluid concentration of gefitinib and erlotinib in patients with non-small cell lung cancer.

Cancer chemotherapy and pharmacology - 1 Sept 2012

Togashi Yosuke, Masago Katsuhiro, Masuda Satohiro, Mizuno Tomoyuki, Fukudo Masahide, Ikemi Yasuaki, Sakamori Yuichi, Nagai Hiroki, Kim Young Hak, Katsura Toshiya, Mishima Michiaki

Abstract excerpt

PURPOSE: Several cases have been reported in which central nervous system (CNS) metastases of non-small cell lung cancer (NSCLC) resistant to gefitinib were improved by erlotinib. However, there has been no study in which cerebrospinal fluid (CSF) concentrations of gefitinib and erlotinib are directly compared. Thus, we aimed to compare them. METHODS: We examined 15 Japanese patients with NSCLC and CNS metastases...

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PMID: 22806307
DOI: 10.1007/s00280-012-1929-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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