Article
Genetic polymorphisms of Wnt/β-catenin pathway genes are associated with the efficacy and toxicities of radiotherapy in patients with nasopharyngeal carcinoma.
Oncotarget - 13 Dec 2016
Yu Jingjing, Huang Yuling, Liu Lijuan, Wang Jing, Yin Jiye, Huang Lihua, Chen Shaojun, Li Jingao, Yuan Hong, Yang Guoping, Liu Wenyu, Wang Hai, Pei Qi, Guo Chengxian
Abstract excerpt
Radiotherapy (RT) is the normative therapeutic treatment for primary nasopharyngeal carcinoma (NPC). Single nucleotide polymorphisms (SNPs) of genes in Wnt/β-catenin pathway are correlated to the development, prognosis, and treatment benefit of various cancers. However, it has not been established whether SNPs of Wnt/β-catenin pathway are associated with nasopharyngeal tumorigenesis and the efficacy of RT in NPC...
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