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Article

Myocardin sumoylation transactivates cardiogenic genes in pluripotent 10T1/2 fibroblasts.

Molecular and cellular biology - 1 Jan 2007

Wang Jun, Li AnKang, Wang ZhiGao, Feng XinHua, Olson Eric N, Schwartz Robert J

Abstract excerpt

Myocardin, a serum response factor (SRF)-dependent cofactor, is a potent activator of smooth muscle gene activity but a poor activator of cardiogenic genes in pluripotent 10T1/2 fibroblasts. Posttranslational modification of GATA4, another myocardin cofactor, by sumoylation strongly activated car...

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Source

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Identifiers

PMID: 17101795
DOI: 10.1128/MCB.01160-06
PMCID: PMC1800801

Genes

PIAS1
SRF
GATA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17101795-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Myocardin sumoylation transactivates cardiogenic genes in pluripotent 10T1/2 fibroblasts.PMID 17101795Read ↗

SUMO-1 modification activated GATA4-dependent cardiogenic gene activity.Semantic proximity Read ↗

Sumoylation and Regulation of Cardiac Gene ExpressionSemantic proximity Read ↗

SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4.Semantic proximity Read ↗

Stem cells and their derivatives can bypass the requirement of myocardin for smooth muscle gene expression.Semantic proximity Read ↗

Myocardin-related transcription factors are required for cardiac development and functionSemantic proximity Read ↗

Myocardin is a master regulator of smooth muscle gene expression.Semantic proximity Read ↗

Direct Reprogramming of Fibroblasts Into Smooth Muscle-Like Cells With Defined Transcription Factors-Brief Report.Semantic proximity Read ↗

Myocardin Induces Cardiomyocyte HypertrophySemantic proximity Read ↗

Transcriptional Control of Cell Lineage Development in Epicardium-Derived CellsSemantic proximity Read ↗

Myocardin is sufficient and necessary for cardiac gene expression in Xenopus.Semantic proximity Read ↗

miR-1/133a clusters cooperatively specify the cardiomyogenic lineage by adjustment of myocardin levels during embryonic heart development.Semantic proximity Read ↗

The serum response factor coactivator myocardin is required for vascular smooth muscle development.Semantic proximity Read ↗

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