Article
Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia.
British journal of haematology - 1 Jan 2017
Brown Fiona C, Cifani Paolo, Drill Esther, He Jie, Still Eric, Zhong Shan, Balasubramanian Sohail, Pavlick Dean, Yilmazel Bahar, Knapp Kristina M, Alonzo Todd A, Meshinchi Soheil, Stone Richard M, Kornblau Steven M, Marcucci Guido, Gamis Alan S, Byrd John C, Gonen Mithat, Levine Ross L, Kentsis Alex
Abstract excerpt
Cure rates of children and adults with acute myeloid leukaemia (AML) remain unsatisfactory partly due to chemotherapy resistance. We investigated the genetic basis of AML in 107 primary cases by sequencing 670 genes mutated in haematological malignancies. SETBP1, ASXL1 and RELN mutations were significantly associated with primary chemoresistance. We identified genomic alterations not previously described in AML,...
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