Article
Clinical relevance of molecular aberrations in paediatric acute myeloid leukaemia at first relapse.
British journal of haematology - 1 Sept 2014
Bachas Costa, Schuurhuis Gerrit Jan, Reinhardt Dirk, Creutzig Ursula, Kwidama Zinia J, Zwaan C Michel, van den Heuvel-Eibrink Marry M, De Bont Evelina S J M, Elitzur Sarah, Rizzari Carmelo, de Haas Valérie, Zimmermann Martin, Cloos Jacqueline, Kaspers Gertjan J L
Abstract excerpt
Outcome for relapsed paediatric acute myeloid leukaemia (AML) remains poor. Strong prognostic factors at first relapse are lacking, which hampers optimization of therapy. We assessed the frequency of molecular aberrations (FLT3, NRAS, KRAS, KIT, WT1 and NPM1 genes) at first relapse in a large set (n = 198) of relapsed non-French-American-British M3, non-Down syndrome AML patients that received similar relapse...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.