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Article

Convert your favorite protein modeling program into a mutation predictor: "MODICT".

BMC bioinformatics - 19 Oct 2016

Tanyalcin Ibrahim, Stouffs Katrien, Daneels Dorien, Al Assaf Carla, Lissens Willy, Jansen Anna, Gheldof Alexander

Abstract excerpt

BACKGROUND: Predict whether a mutation is deleterious based on the custom 3D model of a protein. RESULTS: We have developed MODICT, a mutation prediction tool which is based on per residue RMSD (root mean square deviation) values of superimposed 3D protein models. Our mathematical algorithm was tested for 42 described mutations in multiple genes including renin (REN), beta-tubulin (TUBB2B), biotinidase (BTD),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27760515
DOI: 10.1186/s12859-016-1286-0
PMCID: PMC5070100

Genes

ACADM
BTD
PAH
REN
SMPD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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