Article
Reproducibility of Digital PCR Assays for Circulating Tumor DNA Analysis in Advanced Breast Cancer.
PloS one - 1 Jan 2016
Hrebien Sarah, O'Leary Ben, Beaney Matthew, Schiavon Gaia, Fribbens Charlotte, Bhambra Amarjit, Johnson Richard, Garcia-Murillas Isaac, Turner Nicholas
Abstract excerpt
Circulating tumor DNA (ctDNA) analysis has the potential to allow non-invasive analysis of tumor mutations in advanced cancer. In this study we assessed the reproducibility of digital PCR (dPCR) assays of circulating tumor DNA in a cohort of patients with advanced breast cancer and assessed delayed plasma processing using cell free DNA preservative tubes. We recruited a cohort of 96 paired samples from 71 women...
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