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Article

A type 2 ryanodine receptor variant associated with reduced Ca2+ release and short-coupled torsades de pointes ventricular arrhythmia.

Heart rhythm - 1 Jan 2017

Fujii Yusuke, Itoh Hideki, Ohno Seiko, Murayama Takashi, Kurebayashi Nagomi, Aoki Hisaaki, Blancard Malorie, Nakagawa Yoshihisa, Yamamoto Satoshi, Matsui Yumie, Ichikawa Mari, Sonoda Keiko, Ozawa Tomoya, Ohkubo Kimie, Watanabe Ichiro, Guicheney Pascale, Horie Minoru

Abstract excerpt

BACKGROUND: Ventricular fibrillation may be caused by premature ventricular contractions (PVCs) whose coupling intervals are <300 ms, a characteristic of the short-coupled variant of torsades de pointes (scTdP). OBJECTIVE: The purpose of this study was to analyze the underlying cardiac ryanodine receptor (RyR2) variants in patients with scTdP. METHODS: Seven patients with scTdP (mean age 34 ± 12 years; 4 men and...

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Identifiers

PMID: 27756708
DOI: 10.1016/j.hrthm.2016.10.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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