Circulating granulysin levels in healthcare workers and latent tuberculosis infection estimated using interferon-gamma release assays.

doi:10.1186/s12879-016-1911-6

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Circulating granulysin levels in healthcare workers and latent tuberculosis infection estimated using interferon-gamma release assays.

BMC infectious diseases - 18 Oct 2016

Thuong Pham Huu, Tam Do Bang, Sakurada Shinsaku, Hang Nguyen Thi Le, Hijikata Minako, Hong Le Thi, Ngoc Phan Thi Minh, Anh Pham Thu, Cuong Vu Cao, Matsushita Ikumi, Lien Luu Thi, Keicho Naoto

Abstract excerpt

BACKGROUND: Granulysin (GNLY) is produced by human lymphocyte subpopulations and exhibits antimicrobial activity against Mycobacterium tuberculosis. We examined the association between GNLY levels in blood and latent tuberculosis (TB) infection. METHODS: Latency of TB infection among Vietnamese healthcare workers was estimated using interferon-gamma release assays (IGRA), and serum GNLY concentrations were...

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Circulating granulysin levels in healthcare workers and latent tuberculosis infection estimated using interferon-gamma release assays.

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