Article
Digital PCR of Genomic Rearrangements for Monitoring Circulating Tumour DNA.
Advances in experimental medicine and biology - 1 Jan 2016
Do Hongdo, Cameron Daniel, Molania Ramyar, Thapa Bibhusal, Rivalland Gareth, Mitchell Paul L, Murone Carmel, John Thomas, Papenfuss Anthony, Dobrovic Alexander
Abstract excerpt
Identifying circulating tumour DNA (ctDNA) for monitoring of cancer therapy is dependent on the development of readily designed, sensitive cancer-specific DNA markers. Genomic rearrangements that are present in the vast majority of cancers provide such markers.Tumour DNA isolated from two fresh-frozen lung tumours underwent whole genome sequencing. Genomic rearrangements were detected using a new computational...
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