Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic basis for aberrant upregulation of autoantigen genes in humans with ANCA vasculitis

16 Aug 2010

Abstract excerpt

Antineutrophil cytoplasmic autoantibody (ANCA) causes vascular injury that leads to small-vessel vasculitis. Patients with ANCA aberrantly express neutrophil granule-encoding genes, including 2 that encode autoantigens: proteinase 3 (PR3) and myeloperoxidase (MPO). To uncover a potential transcriptional regulatory mechanism for PR3 and MPO disrupted in patients with ANCA vasculitis, we examined the PR3 and MPO...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eosinophilic Disorders and Syndromes
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Share to Vasculitis and related conditions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20714105
DOI: 10.1172/jci40034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic basis for aberrant upregulation of autoantigen genes in humans with ANCA vasculitisPMID 20714105Read ↗

Histone modification signature at myeloperoxidase and proteinase 3 in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitisSemantic proximity Read ↗

Gene-Specific DNA Methylation Changes Predict Remission in Patients with ANCA-Associated VasculitisSemantic proximity Read ↗

Recent pathogenetic advances in ANCA-associated vasculitis.Semantic proximity Read ↗

Epigenetics and Vasculitis: a Comprehensive Review.Semantic proximity Read ↗

An update on the role of epigenetics in systemic vasculitisSemantic proximity Read ↗

PRTN3 variant correlates with increased autoantigen levels and relapse risk in PR3-ANCA versus MPO-ANCA diseaseSemantic proximity Read ↗

Dysregulation of Autoantigen Genes in ANCA-Associated Vasculitis Involves Alternative Transcripts and New Protein SynthesisSemantic proximity Read ↗

Genetics and pathophysiology of granulomatosis with polyangiitis (GPA) and its main autoantigen proteinase 3.Semantic proximity Read ↗

Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status.Semantic proximity Read ↗

The genetics of anti-neutrophil cytoplasmic antibody associated vasculitis (AAV)Semantic proximity Read ↗

New insights into clinical spectrum of antineutrophil cytoplasmic autoantibody associated disease.Semantic proximity Read ↗

Republished: Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.