Article
Decreased expression of miR‑9 due to E50K OPTN mutation causes disruption of the expression of BDNF leading to RGC‑5 cell apoptosis.
Molecular medicine reports - 1 Nov 2016
Jiang Bo, Gao Lin, Lei Dawei, Liu Jiannan, Shao Zhengbo, Zhou Xinrong, Li Renke, Wu Donglai, Xue Fei, Zhu Yuanmao, Yuan Huiping
Abstract excerpt
The aims of the present study were to investigate the effect of E50K optineurin (OPTN) mutation on RGC‑5 cells and to define the role of microRNA‑9 (miR‑9) in this system. Transfected RGC‑5 cells were used to evaluate the effects of E50K OPTN on the expression of miR‑9 and subsequent disruption of RGC‑5 cell apoptosis was analyzed using western blotting. The results showed that the expression of E50K OPTN was...
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