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Article

FCGR Polymorphisms Influence Response to IL2 in Metastatic Renal Cell Carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2017

Erbe Amy K, Wang Wei, Goldberg Jacob, Gallenberger Mikayla, Kim KyungMann, Carmichael Lakeesha, Hess Dustin, Mendonca Eneida A, Song Yiqiang, Hank Jacquelyn A, Cheng Su-Chun, Signoretti Sabina, Atkins Michael, Carlson Alexander, Mier James W, Panka David J, McDermott David F, Sondel Paul M

Abstract excerpt

Purpose: Fc-gamma receptors (FCGRs) are expressed on immune cells, bind to antibodies, and trigger antibody-induced cell-mediated antitumor responses when tumor-reactive antibodies are present. The affinity of the FCGR/antibody interaction is variable and dependent upon FCGR polymorphisms. Prior studies of patients with cancer treated with immunotherapy indicate that FCGR polymorphisms can influence antitumor...

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Identifiers

PMID: 27742794
DOI: 10.1158/1078-0432.CCR-16-1874
PMCID: PMC5392177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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