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Transcriptomic analysis of ileal tissue from Crohn's disease patients identifies extracellular matrix genes that distinguish individuals by age at diagnosis.

Physiological genomics - 1 Oct 2020

Eshelman Melanie A, Harris Leonard, Deiling Sue, Koltun Walter A, Jeganathan N Arjun, Yochum Gregory S

Abstract excerpt

Crohn's disease (CD) is a debilitating gastrointestinal (GI) disorder that can impact the entirety of the GI tract. While substantial progress has been made in the medical management of CD, it remains incurable, frequently relapses, and is a significant financial and medical burden. The pathophysiology of CD is not well understood, but it is thought to arise in genetically susceptible individuals upon an...

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PMID: 32866088
DOI: 10.1152/physiolgenomics.00062.2020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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