Article
HSV-1 clinical isolates with unique in vivo and in vitro phenotypes and insight into genomic differences.
Journal of neurovirology - 1 Apr 2017
Danaher Robert J, Fouts Derrick E, Chan Agnes P, Choi Yongwook, DePew Jessica, McCorrison Jamison M, Nelson Karen E, Wang Chunmei, Miller Craig S
Abstract excerpt
Strain-specific factors contribute in significant but undefined ways to the variable incidence of herpes simplex virus (HSV) recrudescence. Studies that investigate these strain-specific factors are needed. Here, we used qPCR, in vitro assays, and genomic sequencing to identify important relationships between in vitro and clinical phenotypes of unique HSV-1 clinical isolates. Nine HSV-1 isolates from individuals...
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