Article
Sunitinib in the therapy of malignant paragangliomas: report on the efficacy in a SDHB mutation carrier and review of the literature.
Archives of endocrinology and metabolism - 1 Jan 2000
Canu Letizia, Pradella Silvia, Rapizzi Elena, Fucci Rossella, Valeri Andrea, Briganti Vittorio, Giachè Valentino, Parenti Gabriele, Ercolino Tonino, Mannelli Massimo
Abstract excerpt
Metastatic pheochromocytomas (PHEOs) and paragangliomas (sPGLs) are rare neural crest-derived tumors with a poor prognosis. About 50% of them are due to germ-line mutations of the SDHB gene. At present, there is no cure for these tumors. Their therapy is palliative and represented by different options among which antiangiogenic drugs, like sunitinib, have been hypothesized to be effective especially in malignant...
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