Article
Teriparatide Treatment in Patients With WNT1 or PLS3 Mutation-Related Early-Onset Osteoporosis: A Pilot Study.
The Journal of clinical endocrinology and metabolism - 1 Feb 2017
Välimäki Ville-Valtteri, Mäkitie Outi, Pereira Renata, Laine Christine, Wesseling-Perry Katherine, Määttä Jorma, Kirjavainen Mikko, Viljakainen Heli, Välimäki Matti J
Abstract excerpt
Context: We previously identified 2 Finnish families with dominantly inherited, low-turnover osteoporosis caused by mutations in WNT1 or PLS3. Objective, Design, and Setting: This prospective, longitudinal, uncontrolled study was undertaken to evaluate whether these patients respond to teriparatide. Patients and Intervention: We recruited 6 adults (median age, 54 years); 3 with a WNT1 missense mutation, c.652T>G,...
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