Article
Plastin 3 influences bone homeostasis through regulation of osteoclast activity.
Human molecular genetics - 15 Dec 2018
Neugebauer Janine, Heilig Juliane, Hosseinibarkooie Seyyedmohsen, Ross Bryony C, Mendoza-Ferreira Natalia, Nolte Franziska, Peters Miriam, Hölker Irmgard, Hupperich Kristina, Tschanz Theresa, Grysko Vanessa, Zaucke Frank, Niehoff Anja, Wirth Brunhilde
Abstract excerpt
Over 200 million people suffer from osteoporosis worldwide, one third of which will develop osteoporotic bone fractures. Unfortunately, no effective cure exists. Mutations in plastin 3 (PLS3), an F-actin binding and bundling protein, cause X-linked primary osteoporosis in men and predisposition to osteoporosis in postmenopausal women. Moreover, the strongest association so far for osteoporosis in elderly women...
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