Article
Impaired bone strength and bone microstructure in a novel early-onset osteoporotic rat model with a clinically relevant PLS3 mutation.
eLife - 21 Apr 2023
Hu Jing, Zhou Bingna, Lin Xiaoyun, Zhang Qian, Guan Feifei, Sun Lei, Liu Jiayi, Wang Ou, Jiang Yan, Xia Wei-Bo, Xing Xiaoping, Li Mei
Abstract excerpt
Plastin 3 (PLS3), a protein involved in formation of filamentous actin (F-actin) bundles, is important in human bone health. Recent studies identify PLS3 as a novel bone regulator and PLS3 mutations can lead to a rare monogenic early-onset osteoporosis. However, the mechanism of PLS3 mutation leading to osteoporosis is unknown, and its effective treatment strategies have not been established. Here, we have...
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