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Bone material properties and response to teriparatide in osteoporosis due to WNT1 and PLS3 mutations.

Bone - 1 May 2021

Fratzl-Zelman Nadja, Wesseling-Perry Katherine, Mäkitie Riikka E, Blouin Stéphane, Hartmann Markus A, Zwerina Jochen, Välimäki Ville-Valtteri, Laine Christine M, Välimäki Matti J, Pereira Renata C, Mäkitie Outi

Abstract excerpt

CONTEXT: Patients with osteoporosis-associated WNT1 or PLS3 mutations have unique bone histomorphometric features and osteocyte-specific hormone expression patterns. OBJECTIVE: To investigate the effects of WNT1 and PLS3 mutations on bone material properties. DESIGN: Transiliac bone biopsies were evaluated by quantitative backscattered electron imaging, immunohistochemistry, and bone histomorphometry. SETTING:...

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PMID: 33618074
DOI: 10.1016/j.bone.2021.115900

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