Article
Genome-wide association studies identified novel loci for non-high-density lipoprotein cholesterol and its postprandial lipemic response.
Human genetics - 1 Jul 2014
An Ping, Straka Robert J, Pollin Toni I, Feitosa Mary F, Wojczynski Mary K, Daw E Warwick, O'Connell Jeffrey R, Gibson Quince, Ryan Kathleen A, Hopkins Paul N, Tsai Michael Y, Lai Chao-Qiang, Province Michael A, Ordovas Jose M, Shuldiner Alan R, Arnett Donna K, Borecki Ingrid B
Abstract excerpt
Non-high-density lipoprotein cholesterol(NHDL) is an independent and superior predictor of CVD risk as compared to low-density lipoprotein alone. It represents a spectrum of atherogenic lipid fractions with possibly a distinct genomic signature. We performed genome-wide association studies (GWAS) to identify loci influencing baseline NHDL and its postprandial lipemic (PPL) response. We carried out GWAS in 4,241...
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