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Why Is there a Limit to the Changes in Myofilament Ca2+-Sensitivity Associated with Myopathy Causing Mutations?

26 Sept 2016

Abstract excerpt

Mutations in striated muscle contractile proteins have been found to be the cause of a number of inherited muscle diseases; in most cases the mechanism proposed for causing the disease is derangement of the thin filament-based Ca2+- regulatory system of the muscle. When considering the results of experiments reported over the last 15 years , one feature has been frequently noted, but rarely discussed. The...

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PMID: 27725803
DOI: 10.3389/fphys.2016.00415

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