Article

Viral expression of a SERCA2a-activating PLB mutant improves calcium cycling and synchronicity in dilated cardiomyopathic hiPSC-CMs

2019-07-11

Abstract excerpt

There is increasing momentum toward the development of gene therapy for heart failure (HF), cardiomyopathy, and other progressive cardiac diseases that correlate with impaired calcium (Ca 2+ ) transport and reduced contractility. We have used FRET between fluorescently-tagged SERCA2a (the cardiac Ca 2+ pump) and PLB (its ventricular peptide inhibitor) to test directly the effectiveness of loss-of-inhibition/gain...

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Literature Corpus work: 97e6030e-745e-53ff-9a27-7677c016fee7
DOI: 10.1101/699975

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