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Article

Longitudinal mutational analysis of a cerebellar pilocytic astrocytoma recurring as a ganglioglioma.

Pediatric blood & cancer - 1 Feb 2017

Fiset Pierre O, Fontebasso Adam M, De Jay Nicolas, Gayden Tenzin, Nikbakht Hamid, Majewski Jacek, Jabado Nada, Albrecht Steffen

Abstract excerpt

A cerebellar pilocytic astrocytoma (PA) in a child recurred first with a PA histology and then with features of a ganglioglioma (GG). Molecular genetic analyses of the tumors confirmed a BRAF V600E mutation in all. They also all harbored a T202M mutation in ERK1, a kinase downstream of BRAF that is implicated in glial versus neuronal differentiation. The GG sample contained several variants that were not present...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasm Recurrence, Local

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Share to Proto-Oncogene Proteins B-raf

Source

Identifiers

PMID: 27718322
DOI: 10.1002/pbc.26215

Genes

BRAF
MAP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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