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L1 and L2 gene polymorphisms in HPV-58 and HPV-33: implications for vaccine design and diagnosis

7 Oct 2016

Abstract excerpt

BACKGROUND: Cervical cancer is associated with infection by certain subtypes of human papillomavirus (HPV). The L1 protein comprising HPV vaccine formulations elicits high-titre neutralizing antibodies and confers protection against specific HPV subtypes. HPV L2 protein is an attractive candidate for cross-protective vaccines. HPV-33 and HPV-58 are very prevalent among Chinese women. METHODS: To study the gene...

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PMID: 27717385
DOI: 10.1186/s12985-016-0629-9

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