Article
Genetic variability in L1 and L2 genes of HPV-16 and HPV-58 in Southwest China.
PloS one - 1 Jan 2013
Yue Yaofei, Yang Hongying, Wu Kun, Yang Lijuan, Chen Junying, Huang Xinwei, Pan Yue, Ruan Youqing, Zhao Yujiao, Shi Xinan, Sun Qiangming, Li Qihan
Abstract excerpt
HPV account for most of the incidence of cervical cancer. Approximately 90% of anal cancers and a smaller subset (<50%) of other cancers (oropharyngeal, penile, vaginal, vulvar) are also attributed to HPV. The L1 protein comprising HPV vaccine formulations elicits high-titre neutralizing antibodies and confers type restricted protection. The L2 protein is a promising candidate for a broadly protective HPV...
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