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Identification of variants and therapeutic epitopes in HPV-33/HPV-58 E6 and E7 in Southwest China

28 May 2019

Abstract excerpt

BACKGROUND: Human papillomavirus (HPV) E6 and E7 oncoproteins play a crucial role in HPV-related diseases, such as cervical cancer, and can be used as ideal targets for therapeutic vaccines. Human leukocyte antigen (HLA) participates in the immune response to block HPV infection and invasion by its target/recognition function. HPV-33 and HPV-58 are highly prevalent among Chinese women. Therefore, it is of great...

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PMID: 31138240
DOI: 10.1186/s12985-019-1168-y

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