Article
E6 and E7 Gene Polymorphisms in Human Papillomavirus Types-58 and 33 Identified in Southwest China.
PloS one - 1 Jan 2017
Chen Zuyi, Jing Yaling, Wen Qiang, Ding Xianping, Wang Tao, Mu Xuemei, Chenzhang Yuwei, Cao Man
Abstract excerpt
Cancer of the cervix is associated with infection by certain types of human papillomavirus (HPV). The gene variants differ in immune responses and oncogenic potential. The E6 and E7 proteins encoded by high-risk HPV play a key role in cellular transformation. HPV-33 and HPV-58 types are highly prevalent among Chinese women. To study the gene intratypic variations, polymorphisms and positive selections of HPV-33...
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