Article
Regulation of lysosomal phosphoinositide balance by INPP5E is essential for autophagosome-lysosome fusion.
Autophagy - 1 Dec 2016
Nakamura Shuhei, Hasegawa Junya, Yoshimori Tamotsu
Abstract excerpt
Macroautophagy (autophagy) is a multistep intracellular degradation system. Autophagosomes form, mature, and ultimately fuse with lysosomes, where their sequestered cargo molecules are digested. In contrast to autophagosome formation, our knowledge of autophagosome-lysosome fusion is limited. In a recent study, we identified a novel regulator of autophagy, INPP5E (inositol polyphosphate-5-phosphatase E), which is...
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