Article
Fine mapping of the GWAS loci identifies SLC35D1 and IL23R as potential risk genes for leprosy.
Journal of dermatological science - 1 Dec 2016
Li Guo-Dong, Wang Dong, Zhang Deng-Feng, Xiang Qun, Feng Jia-Qi, Li Xiao-An, Li Yu-Ye, Yao Yong-Gang
Abstract excerpt
BACKGROUND: Previous genome-wide association study (GWAS) identified two new leprosy associated loci (1p31.3 [rs3762318] and 6q24.3 [rs2275606]). However, there were insufficient validations in independent populations. OBJECTIVE: To validate the association and to map the potentially causal variants/genes underlying the association between the confirmed GWAS hit and leprosy. METHODS: We genotyped 10 variants in...
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