Article
Behçet disease-associated MHC class I residues implicate antigen binding and regulation of cell-mediated cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America - 17 Jun 2014
Ombrello Michael J, Kirino Yohei, de Bakker Paul I W, Gül Ahmet, Kastner Daniel L, Remmers Elaine F
Abstract excerpt
The HLA protein, HLA-B*51, encoded by HLA-B in MHC, is the strongest known genetic risk factor for Behçet disease (BD). Associations between BD and other factors within the MHC have been reported also, although strong regional linkage disequilibrium complicates their confident disentanglement from HLA-B*51. In the current study, we examined a combination of directly obtained and imputed MHC-region SNPs, directly...
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