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Article

A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 Oct 2016

Fleming Michael S, Li Jian J, Ramos Daniel, Li Tong, Talmage David A, Abe Shin-Ichi, Arber Silvia, Luo Wenqin

Abstract excerpt

Axon-Schwann cell interactions are crucial for the development, function, and repair of the peripheral nervous system, but mechanisms underlying communication between axons and nonmyelinating Schwann cells are unclear. Here, we show that ER81 is functionally required in a subset of mouse RET+ mechanosensory neurons for formation of Pacinian corpuscles, which are composed of a single myelinated axon and multiple...

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Source

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Identifiers

PMID: 27707970
DOI: 10.1523/JNEUROSCI.2160-16.2016
PMCID: PMC5050328

Genes

RET
NRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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