Article
Epithelioid peritoneal mesothelioma: a hybrid phenotype within a mesenchymal-epithelial/epithelial-mesenchymal transition framework.
Oncotarget - 15 Nov 2016
Bozzi Fabio, Brich Silvia, Dagrada Gian Paolo, Negri Tiziana, Conca Elena, Cortelazzi Barbara, Belfiore Antonino, Perrone Federica, Gualeni Ambra Vittoria, Gloghini Annunziata, Cabras Antonello, Brenca Monica, Maestro Roberta, Zaffaroni Nadia, Casali Paolo, Bertulli Rossella, Deraco Marcello, Pilotti Silvana
Abstract excerpt
The aim of this study was to reconsider the biological characteristics of epithelioid malignant peritoneal mesothelioma (E-MpM) in the light of new concepts about epithelial mesenchymal transition and mesenchymal epithelial reverse transition (EMT/MErT) and the role of epigenetic reprogramming in this context. To this end we profiled surgical specimens and derived cells cultures by a number of complementary...
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