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Article

Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production

1 Oct 2016

Abstract excerpt

Vitamin D insufficiency is a worldwide epidemic affecting billions of individuals, including pregnant women and children. Despite its high incidence, the impact of active vitamin D3 (1,25(OH)D3) on embryonic development beyond osteo-regulation remains largely undefined. Here, we demonstrate that 1,25(OH)D3 availability modulates zebrafish hematopoietic stem and progenitor cell (HSPC) production. Loss of...

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PMID: 27705794
DOI: 10.1016/j.celrep.2016.09.012

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