Article
B cells from African American lupus patients exhibit an activated phenotype.
JCI insight - 16 Jun 2016
Menard Laurence C, Habte Sium, Gonsiorek Waldemar, Lee Deborah, Banas Dana, Holloway Deborah A, Manjarrez-Orduno Nataly, Cunningham Mark, Stetsko Dawn, Casano Francesca, Kansal Selena, Davis Patricia M, Carman Julie, Zhang Clarence K, Abidi Ferva, Furie Richard, Nadler Steven G, Suchard Suzanne J
Abstract excerpt
Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease driven by both innate and adaptive immune cells. African Americans tend to present with more severe disease at an earlier age compared with patients of European ancestry. In order to better understand the immunological differences between African American and European American patients, we analyzed the frequencies of B cell subsets and...
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