Article
Recurrent RHOA mutations in pediatric Burkitt lymphoma treated according to the NHL-BFM protocols.
Genes, chromosomes & cancer - 1 Nov 2014
Rohde Marius, Richter Julia, Schlesner Matthias, Betts Matthew J, Claviez Alexander, Bonn Bettina R, Zimmermann Martin, Damm-Welk Christine, Russell Robert B, Borkhardt Arndt, Eils Roland, Hoell Jessica I, Szczepanowski Monika, Oschlies Ilske, Klapper Wolfram, Burkhardt Birgit, Siebert Reiner
Abstract excerpt
Burkitt lymphoma (BL) is the most frequent B-cell lymphoma in childhood. Genetically, it is characterized by the presence of an IG-MYC translocation which is supposed to be an initiating but not sufficient event in Burkitt lymphomagenesis. In a recent whole-genome sequencing study of four cases, we showed that the gene encoding the ras homolog family member A (RHOA) is recurrently mutated in pediatric BL. Here,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.