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TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence

30 Sept 2016

Abstract excerpt

Human telomerase reverse transcriptase (hTERT) plays a central role in telomere lengthening for continuous cell proliferation, but it remains unclear how extracellular cues regulate telomerase lengthening of telomeres. Here we report that the cytokine bone morphogenetic protein-7 (BMP7) induces the hTERT gene repression in a BMPRII receptor- and Smad3-dependent manner in human breast cancer cells. Chonic exposure...

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PMID: 27696331
DOI: 10.1007/s13238-016-0322-1

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