Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of cGAS-dependent antiviral responses by DNA intercalating agents

29 Sept 2016

Abstract excerpt

Acridine dyes, including proflavine and acriflavine, were commonly used as antiseptics before the advent of penicillins in the mid-1940s. While their mode of action on pathogens was originally attributed to their DNA intercalating activity, work in the early 1970s suggested involvement of the host immune responses, characterized by induction of interferon (IFN)-like activities through an unknown mechanism. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Immune Response and Inflammation
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27694309
DOI: 10.1093/nar/gkw878

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of cGAS-dependent antiviral responses by DNA intercalating agentsPMID 27694309Read ↗

Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cellsSemantic proximity Read ↗

Antimicrobial-Induced DNA Damage and Genomic Instability in Microbial PathogensSemantic proximity Read ↗

A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signalingSemantic proximity Read ↗

STING Mediates Cytosolic Dna-Induced Muc5ac Mrna Expression in Human Bronchial Epithelial CellsSemantic proximity Read ↗

Chronic exposure to Cytolethal Distending Toxin (CDT) promotes a cGAS-dependent type I interferon responseSemantic proximity Read ↗

Bacterial-induced cell fusion is a danger signal triggering cGAS–STING pathway via micronuclei formationSemantic proximity Read ↗

Genistein Targets STING-Driven Antiviral ResponsesSemantic proximity Read ↗

CGAS is a micronucleophagy receptor for the clearance of micronucleiSemantic proximity Read ↗

A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA.Semantic proximity Read ↗

An examination of the role of IFI16 in detecting viral DNA in human immortalised keratinocytesSemantic proximity Read ↗

Investigations on the molecular mode of action of the novel immunostimulator ZelNate: Activation of the cGAS-STING pathway in mammalian cellsSemantic proximity Read ↗

CX-5461 Treatment Leads to Cytosolic DNA-Mediated STING Activation in Ovarian CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.