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CX-5461 Treatment Leads to Cytosolic DNA-Mediated STING Activation in Ovarian Cancer

9 Oct 2021

Abstract excerpt

Epithelial ovarian cancer (EOC) is the deadliest of the gynecologic malignancies, with an overall survival rate of <30%. Recent research has suggested that targeting RNA polymerase I (POL I) with small-molecule inhibitors may be a viable therapeutic approach to combating EOC, even when chemoresistance is present. CX-5461 is one of the most promising POL I inhibitors currently being investigated, and previous...

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PMID: 34680204
DOI: 10.3390/cancers13205056

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