Article
RHOA mutation in follicular T-cell lymphoma: Clinicopathological analysis of 16 cases.
Pathology international - 1 Sept 2020
Miyoshi Hiroaki, Sakata-Yanagimoto Mamiko, Shimono Joji, Yoshida Noriaki, Hattori Keiichiro, Arakawa Fumiko, Yanagida Eriko, Takeuchi Mai, Yamada Kyohei, Suzuki Takaharu, Moritsubo Mayuko, Furuta Takuya, Chiba Shigeru, Ohshima Koichi
Abstract excerpt
Follicular T-cell lymphoma (FTCL) is considered to originate from follicular helper T-cell (Tfh) cells. Angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphomas with the Tfh phenotype, derived from Tfh cells, often harbor RHOA G17V mutation. We investigated whether RHOA mutations affect the clinicopathological features of FTCL. We performed deep sequencing and Sanger sequencing for RHOA exon 2 in...
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