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Paraoxonase 1 status is a major Janus-faced component of mild and moderate acute ischemic stroke and consequent disabilities.

Metabolic brain disease - 1 Aug 2023

Brinholi Francis F, Michelin Ana Paula, Matsumoto Andressa K, de O Semeão Laura, Almulla Abbas F, Supasitthumrong Thitiporn, Tunvirachaisakul Chavit, Barbosa Décio S, Maes Michael

Abstract excerpt

AIMS: This study aims to examine the associations between paraoxonase 1 (PON)1 status and acute ischemic stroke (AIS) and consequent disabilities. METHODS: This study recruited 122 patients with AIS and 40 healthy controls and assessed the Q192R gene variants, arylesterase (AREase) and chloromethyl phenylacetate (CMPAase) activities, and high-density lipoprotein cholesterol (HDLc) in baseline conditions. AREase...

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PMID: 37204661
DOI: 10.1007/s11011-023-01232-4

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