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Article

Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys.

Science translational medicine - 4 May 2011

Letvin Norman L, Rao Srinivas S, Montefiori David C, Seaman Michael S, Sun Yue, Lim So-Yon, Yeh Wendy W, Asmal Mohammed, Gelman Rebecca S, Shen Ling, Whitney James B, Seoighe Cathal, Lacerda Miguel, Keating Sheila, Norris Philip J, Hudgens Michael G, Gilbert Peter B, Buzby Adam P, Mach Linh V, Zhang Jinrong, Balachandran Harikrishnan, Shaw George M, Schmidt Stephen D, Todd John-Paul, Dodson Alan, Mascola John R, Nabel Gary J

Abstract excerpt

The RV144 vaccine trial in Thailand demonstrated that an HIV vaccine could prevent infection in humans and highlights the importance of understanding protective immunity against HIV. We used a nonhuman primate model to define immune and genetic mechanisms of protection against mucosal infection by the simian immunodeficiency virus (SIV). A plasmid DNA prime/recombinant adenovirus serotype 5 (rAd5) boost vaccine...

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Identifiers

PMID: 21543722
DOI: 10.1126/scitranslmed.3002351
PMCID: PMC3718279

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TRIM5

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