Article
TERT mutations and aggressive histopathologic characteristics of radioiodine-refractory papillary thyroid cancer
11 Sept 2024
Abstract excerpt
BACKGROUND: Radioiodine (RI) ablation following thyroid-stimulating hormone suppression is an effective treatment for papillary thyroid cancer (PTC), typically leading to favorable outcomes. However, RI-refractory tumors exhibit aggressive behavior and poor prognoses. Recent studies highlight the role of genetic abnormalities in PTC signaling pathways, including the activation of telomerase reverse transcriptase...
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