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Genetic polymorphisms of BACH2, a key gene regulating Th2 immune response, increasing risk of allergic rhinitis.

Gene - 30 Oct 2024

Li Xiaobo, Gao Huiping, Liu Lizhen, Yang Yanlong, Sun Shengli, Liu Yonglin

Abstract excerpt

BACKGROUND: Allergic rhinitis (AR) is an allergic disease characterized by the dominant differentiation of T helper cell 2 (Th2). BACH2 plays a key role in regulating Th2 immune response. This study aimed to explore the association between BACH2 single nucleotide polymorphism (SNPs) and susceptibility to AR. METHODS: Han population from northern Shaanxi, China was chosen as subjects. After the DNA extraction from...

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PMID: 38824974
DOI: 10.1016/j.gene.2024.148624

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