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Article

XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer.

Nature - 6 Oct 2016

Kim Jimi, McMillan Elizabeth, Kim Hyun Seok, Venkateswaran Niranjan, Makkar Gurbani, Rodriguez-Canales Jaime, Villalobos Pamela, Neggers Jasper Edgar, Mendiratta Saurabh, Wei Shuguang, Landesman Yosef, Senapedis William, Baloglu Erkan, Chow Chi-Wan B, Frink Robin E, Gao Boning, Roth Michael, Minna John D, Daelemans Dirk, Wistuba Ignacio I, Posner Bruce A, Scaglioni Pier Paolo, White Michael A

Abstract excerpt

The common participation of oncogenic KRAS proteins in many of the most lethal human cancers, together with the ease of detecting somatic KRAS mutant alleles in patient samples, has spurred persistent and intensive efforts to develop drugs that inhibit KRAS activity. However, advances have been hindered by the pervasive inter- and intra-lineage diversity in the targetable mechanisms that underlie KRAS-driven...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27680702
DOI: 10.1038/nature19771
PMCID: PMC5161658

Genes

KRAS
XPO1
FSTL5
YAP1
NFKBIA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer.PMID 27680702Read ↗

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