A functional variant at the miRNA binding site in E2F1 gene is associated with risk and tumor HPV16 status of oropharynx squamous cell carcinoma.

doi:10.1002/mc.22576

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A functional variant at the miRNA binding site in E2F1 gene is associated with risk and tumor HPV16 status of oropharynx squamous cell carcinoma.

Molecular carcinogenesis - 1 Mar 2017

Yuan Ying, Sturgis Erich M, Zhu Lijun, Lu Meixia, Li Yuncheng, Wei Qingyi, Li Guojun

Abstract excerpt

Human papillomavirus (HPV) activates E2F1-driven transcription via the E7-RB1-E2F pathway. Genetic polymorphisms in the 3' untranslated region (UTR) targeted by miRNAs can affect the regulation of target genes and individual cancer risk. Thus, we hypothesized that a polymorphism at the 3'UTR miRNA binding site of E2F1 gene (rs3213180) was associated with risk of oral squamous cell carcinoma (OSCC) and tumor HPV...

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PMID: 27677255
DOI: 10.1002/mc.22576

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