Article

Characterization of human immunodeficiency virus (HIV-1) envelope glycoprotein variants selected for resistance to a CD4-mimetic compound

2022-04-23

Abstract excerpt

<h4>ABSTRACT</h4> Binding to host cell receptors, CD4 and CCR5/CXCR4, triggers conformational changes in the human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer that promote virus entry. CD4 binding allows the gp120 exterior Env to bind CCR5/CXCR4 and induces a pre-hairpin intermediate conformation in the gp41 transmembrane Env. Small-molecule CD4-mimetic compounds (CD4mcs) bind within the con...

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Literature Corpus work: a9adcc17-e4e3-5f97-b97d-b5b37080e55a
DOI: 10.1101/2022.04.21.489129

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